FOR ANIMAL TREATMENT ONLY

An aid in the control of chronic respiratory disease (CRD) caused by M. gallisepticum (MG) in susceptible (MG free) chickens at risk of infection.

Susceptible (MG free) layer flocks vaccinated with Vaxsafe® MG vaccine prior to MG challenge exhibit less respiratory disease, require less anti-microbial medication and during lay will produce more eggs than comparably challenged non-vaccinated flocks. Safety testing has shown M. gallisepticum Strain ts-11 to be virtually non-pathogenic in chickens and not readily transmitted between birds.

Contents: Vaxsafe® MG is supplied frozen in a plastic peel-top eye- dropper vial containing 30mL vaccine, sufficient for 1000 doses by eye drop application.
DIRECTIONS FOR USE:
Contraindications:
• This product is contraindicated for vaccinating unhealthy birds.
• This product is contraindicated for vaccination of birds undergoing medication with an antimicrobial known to inhibit M. gallisepticum multiplication, eg, Tetracycline, Tiamulin, Tylosin, Enrofloxacin, Lincospectin, Gentamycin or macrolide antibiotics.

Precautions:
• Vaxsafe® MG contains live organisms and correct storage and administration are essential for successful use.
• Do not refreeze Vaxsafe® MG after thawing.
• Withdraw antibiotics from the flock for a period equivalent to the recommended withholding period prior to vaccination and do not use after vaccination.
• Where antibiotics must be used, preference should be given to agents with low mycoplasma activity such as penicillin, amoxycillin or neomycin. They should not be given within 4 weeks after vaccination.
• Do not dilute. Thawed vaccine should be used as supplied.

Dosage and Administration:
• Pullets are normally vaccinated between 6-14 weeks of age with the minimum age for efficacious use being 4 weeks.
• Application is by eye drop.
• All birds in the flock should be vaccinated.
• Vaccination need only be done once. Revaccination is not necessary and is not recommended.

General Instructions:
• Pullets should first be tested for MG infection. Testing for the presence of MG in the flock is normally by way of the rapid serum agglutination test (RSAT) with blood samples being tested within 24 hours of collection.
• Operators should contact their laboratory service for advice on the collection and number of blood samples to be taken.
• Only flocks with no antibodies to MG should be vaccinated. Vaccination of infected birds will not provide any economic benefit.
• Vaccination should be carried out on MG free birds at least 3 weeks before exposure to virulent MG is likely to occur.
• Vaccination can be timed to coincide with other flock management practices (e.g. beak trimming, fowl pox vaccination).

STORAGE INSTRUCTIONS:
Vaxsafe® MG should always be protected from direct sunlight. For long term storage Vaxsafe® MG should be stored at or below -70oC. For short term storage (maximum of 4 weeks) Vaxsafe® MG can be stored in a domestic chest freezer (at or below -18oC).

DISPOSAL:
Discarded unused vaccine and empty vaccine bottles into a disinfectant solution (e.g. chlorine based bleach). Dispose of any such inactivated, unused vaccine and empty containers by wrapping in paper and putting in garbage.
In cases of spillage, soak up the liquid with an absorbent sponge or cloth and incinerate. Treat the surface with a disinfectant solution (e.g. chlorine based bleach).
CAUTION:
The capability of this vaccine to produce satisfactory results depends upon many factors including, but not limited to, conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of individual birds and degree of field exposure. Therefore, directions for use should be followed carefully.